Relationship, association and distribution of Helicobacter pylori infection in endoscopy patients at a Tertiary Hospital in Makurdi, Benue State, Nigeria to the symptoms of nausea and vomiting
Department of Microbiology, Joseph Sarwuan Tarka University Makurdi, Benue State, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2024, 21(02), 790–795
Publication history:
Received on 23 December 2023; revised on 29 January 2024; accepted on 01 February 2024
Abstract:
The distribution of H. pylori obtained from patients referred for endoscopy at Benue State University Teaching Hospital (BSUTH) Makurdi, Benue State, Nigeria in relation to nausea and vomiting was examined in this study. To isolate H. pylori, gastric biopsy samples were obtained from the antrum of 80 consenting patients, and questionnaires were administered to them. The biopsies were placed in Brain Heart Infusion (BHI) broth and were used for isolation. Genomic Deoxyribonucleic Acid (gDNA) was extracted from the biopsies using ReliaPrep spin column method and used for singleplex Polymerase Chain Reaction (PCR). Out of the 80 patients, 24 (30%) had H. pylori infection as detected by 16S rRNA PCR. There was no significant association between infection and nausea/vomiting (OR = 5.622, 95% CI: 0.683-46.274; p = 0.076), or infection and hematemesis, common symptoms reported by patients (OR = 0.911, 95% CI: 0.304 - 2.729; p = 0.870). The research sheds light on the infection, prevalence and distribution of H. pylori in endoscopy referral patients at BSUTH, with respect to nausea and vomiting, and provides valuable information for both clinicians and researchers.
Keywords:
Helicobacter pylori; Endoscopy; Distribution; Nausea; Vomiting; Benue State; Nigeria
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