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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Enterobacter Cloacae: The association of antibiotic resistance, integron class I and carbapenemase genes

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  • Enterobacter Cloacae: The association of antibiotic resistance, integron class I and carbapenemase genes

Ahmed Ali Mhawesh *, Reem Naeem Ibraheem and Tamara Husham Zedan

Dept. of Med. and Mol. Biotech., College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.
 
Research Article
World Journal of Advanced Research and Reviews, 2021, 12(02), 549-554
Article DOI: 10.30574/wjarr.2021.12.2.0464
DOI url: https://doi.org/10.30574/wjarr.2021.12.2.0464
 
Received on 16 September 2021; revised on 23 November 2021; accepted on 25 November 2021
 
The opportunistic pathogen, E. Cloacae has been reported to carry carbapenemas genes worldwide. Our objective was assessing the association of antibiotic resistance, integron class I and carbapenemase genes among E. Cloacae. Herein, 200 E. Cloacae were collected and identified. The antibiotic resistance of them was evaluated using Kirby Bauer method. The existence of class I integron, carbapenemase genes was investigated using polymerase chain reaction (PCR). Of the 200 E. Cloacae isolates collected, 120 isolates (60%) were from male and 80 isolates (40%) were from females. Of them, 110 isolates (55%) showed a pattern of MDR phenotype. Of these, 18 isolates (9%) showed resistance to imipenem. Based on PCR test, 134 isolates (67%) had class I integrons. Also, out of 110 MDR isolates, 52 isolates (72%) were positive in terms of the presence of class I integrons. Isolates with integrons were mostly from urinary (61%) and blood (44%) and from ICU settings (46%) and inpatients (38%). A significant relationship was observed between the presence of integron and resistance to ciprofloxacin, imipenem, meropenem, and norfloxacin antibiotics. The prevalence of blaIMP, blaOXA-48 were 18% and 4%, respectively, but none of other carbapenemase genes were detected. The existence of class I integron was high among E. Cloacae from Baghdad city. The carriage of genes resistance to carbapenems were significantly associated to the class I integrin.
 
Enterobacter Cloacae; Antibiotic resistance; Integron class I; Carbapenemase genes
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2021-0464.pdf

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Ahmed Ali Mhawesh, Reem Naeem Ibraheem and Tamara Husham Zedan. Enterobacter Cloacae: The association of antibiotic resistance, integron class I and carbapenemase genes. World Journal of Advanced Research and Reviews, 2021, 12(2), 549-554. Article DOI: https://doi.org/10.30574/wjarr.2021.12.2.0464

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