Vitamin D status and its influence on pregnancy outcomes amongst pregnant women in southeastern Nigeria
1Department of Obstetrics and Gynecology, Nnamdi Azikiwe University and Teaching Hospital (NAUTH), Nnewi, Nigeria.
2Department of chemical pathology, Nnamdi Azikiwe University, Nnewi, Nigeria.
3 Department of community medicine, Nnamdi Azikiwe University and Teaching Hospital, Nnewi, Nigeria.
4 Centre for health and allied legal and demographical development research and training (CHALADDRAT), Nnamdi Azikiwe University, Awka, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2020, 07(02), 089-098
Article DOI: 10.30574/wjarr.2020.7.2.0264
Publication history:
Received on 14 July 2020; revised on 29July 2020; accepted on 07 August 2020
Abstract:
This is a prospective cross-sectional study involving 256 consecutive consenting parturient women in southeastern Nigeria. The study aimed to determine the vitamin D levels of the pregnant women together with its influence on pregnancy outcomes. It involved assay of vitamin D levels from blood samples of the women using High Pressure Liquid Chromatography (HPLC).Vitamin D levels were analyzed in respect of the women’s biodata and pregnancy outcome variables using SPSS. Data comparison was made using chi-square test and student t-test with p-values of<0.05 at 95% confidence interval considered as significant. Of the 256 pregnant women studied, 36(14.1%) had vitamin D deficiency (VDD). Mean serum vitamin D significantly decreased with increasing parity and increasing gestational age up to term (37-42 weeks). There was progressive increase in number of women (normal and vitamin D-deficient) for labour onset between 37th and 42nd weeks. Vitamin D levels did not influence type or mode of delivery. No trend occurred between vitamin D and both antenatal and labour complications and no relationship occurred between serum vitamin D and fetal birth weight; although number of women with VDD increased with increasing placental weight. The prevalence of VDD in pregnant women in this study (14.1%), is low. There is also no associated deleterious pregnancy outcome to justify routine antenatal vitamin D supplementation, as suggested elsewhere. A larger population and multi-centered study may perhaps elucidate further the influence of vitamin D on pregnancy outcome amongst the people in this study area.
Keywords:
Vitamin D; Maternal fetal outcome; pregnant women in southeast Nigeria.
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