Variations of prothrombin time among ABO blood groups in healthy adults
1 Department of Physiotherapy, National Institute of Traumatology and Orthopaedic Rehabilitation, Dhaka, Bangladesh.
2 Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh.
3 Department of Orthopaedics, National Institute of Traumatology andOrthopaedics Rehabilitation, Dhaka, Bangladesh.
4 Department of Cardiology, Kurmitola General Hospital, Dhaka, Bangladesh.
5 Department of Physiology, Mymensingh Medical College and Hospital, Mymensingh, Bangladesh.
6 Department of Physiology, Ibrahim Medical College and Hospital, Dhaka, Bangladesh.
7 Epsom and st helier nhs trust, Epsom, London, UK.
8 Bhairab Upazila Health Complex, Kishoreganj, Bangladesh.
9 Department of Nephrology, Chattogram Medical College and Hospital, Chattogram, Bangladesh
Research Article
World Journal of Advanced Research and Reviews, 2021, 11(03), 429–435
Article DOI: 10.30574/wjarr.2021.11.3.0484
Publication history:
Received on 23 August 2021; revised on 26 September 2021; accepted on 28 September 2021
Abstract:
Background and objectives: ABO blood group distribution defers with racial and geographic variations. They are related with diseases like cardiovascular diseases, cerebral thromboembolism. Prothrombin time may varies among ABO blood group system which may increase the future risk of thrombosis. The present study is to assess prothrombin time among ABO blood groups in healthy adults.
Materials and methods: A prospective type of analytical cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2019 to June 2020. After obtaining ethical clearance, a total 190 healthy adults were selected from different areas of Dhaka city based on inclusion and exclusion criteria, with age ranging from 18-45 years. The subjects were interviewed and detailed history regarding personal, family, medical and drug were taken. Prior to sample collection, informed written consent was taken from the participants. Individuals of blood group A was selected as group A, blood group B as group B, blood group AB as group AB and blood group O as group O. Prothrombin time was measured in the Department of Hematology and BMT Unit, Dhaka Medical College Hospital, Dhaka. Blood grouping was done in the Department of Physiology, Dhaka Medical College, Dhaka.For statistical analysis, One way ANOVA followed by Bonferroni test were considered using SPSS 25.0 version.
Results: In this study, blood group B was most common (33.2%). Prothrombin time was lower in blood group A (12.93±0.30 sec), B (12.92±0.61 sec), AB (12.98±0.54 sec) than blood group O (13.08±0.39 sec) which was not statistically significant.
Conclusion: It can be concluded that blood group A, B, AB individuals may have more chance of thrombosis due to lower prothrombin time than blood group O individuals.
Keywords:
ABO blood groups; Prothrombin time; Healthy adults; Individuals
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