Use of drugs in children with impaired liver function
Gastrohepatology Division, Child Health Department University of Indonesia, Ciptomangunkusomo Hospital.
Review Article
World Journal of Advanced Research and Reviews, 2020, 08(03), 149-153
Article DOI: 10.30574/wjarr.2020.8.3.0475
Publication history:
Received on 03 December 2020; revised on 12 December 2020; accepted on 14 December 2020
Abstract:
Liver disorders in children will affect the pharmacokinetics and pharmacodynamics of drugs that are metabolized in the liver. Chronic liver disease in children such as chronic hepatitis, cirrhosis of the liver can affect the absorption and disposition (pharmacokinetics) of drugs and the efficacy and safety (pharmacodynamics) of drugs in the body. Dosage modification is determined based on clinical studies examining the effects of impaired liver function on the pharmacodynamics and pharmacokinetics of a drug.
Keywords:
Chronic liver disease; Children; Drug dose adjustment
Full text article in PDF:
Copyright information:
Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0