Understanding the Tuberculosis and COVID-19 Co-infection: A Comprehensive Review of Immunopathological Dynamics and Pandemic’s Disruption in TB Services

Alya Rahma Putri Rizanda 1, Manik Retno Wahyunitisari 2, *, Laksmi Wulandari 3 and Brian Eka Rachman 4

1 Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
2 Department of Medical Microbiology, Faculty of Medicine Airlangga University/Dr. Soetomo Regional Public Hospital, Surabaya, Indonesia.
3 Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Airlangga University/Dr. Soetomo Regional Public Hospital, Surabaya, Indonesia.
4 Department of Internal Medicine, Faculty of Medicine Airlangga University/Dr. Soetomo Regional Public Hospital, Surabaya, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 1204–1211
Article DOI: 10.30574/wjarr.2024.24.3.3781
 
Publication history: 
Received on 03 November 2024; revised on 11 December 2024; accepted on 13 December 2024
 
Abstract: 
Tuberculosis (TB) remains a significant public health challenge worldwide and its incidence has been exacerbated by the COVID-19 pandemic. The interaction between TB and COVID-19 poses significant risks to patients, leading to increased morbidity and complicating treatment strategies as both diseases share similar clinical manifestations, such as respiratory symptoms and immune effects. As the global health system continues to grapple with the impact of COVID-19 on existing infectious disease frameworks, it is imperative that researchers engage in research focused on understanding TB co-infection and COVID-19. The primary aim of this literature review is to contribute to the development of knowledge about the pathogenic etiology, clinical manifestations, risk factors, immunopathology of TB and COVID-19 co-infection, and the impact of the COVID-19 pandemic in TB services.
 
Keywords: 
TB; COVID-19; Co-infection; Immunopathology; Service
 
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