Understanding clopidogrel resistance: Mechanisms, detections, implications and surmount the clopidogrel resistant in order to potential solutions

B. V. Raghavendra; J. Naga Lakshmi; K. Naga Anusha; U. Hari tarun; T. Vijay Kumar

doi:10.30574/wjarr.2023.19.2.1408

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 || CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Understanding clopidogrel resistance: Mechanisms, detections, implications and surmount the clopidogrel resistant in order to potential solutions

B. V. Raghavendra, J. Naga Lakshmi, K. Naga Anusha, U. Hari tarun and T. Vijay Kumar

Department Of Pharmacy Practice, A. M. Reddy Memorial College of Pharmacy, Acharya Nagarjuna University, Narasaraopet, India.

Review Article

World Journal of Advanced Research and Reviews, 2023, 19(02), 907-921

Article DOI: 10.30574/wjarr.2023.19.2.1408

DOI url: https://doi.org/10.30574/wjarr.2023.19.2.1408

Publication history

Received on 14 June 2023; revised on 18 August 2023; accepted on 20 August 2023

Abstract

Clopidogrel, a drug belonging to the thienopyridine class of antiplatelet agents, has been utilized either as a standalone medication or in combination with aspirin for averting vascular complications in patients afflicted with atherothrombotic conditions. The selective and irreversible blockade of the P2Y12 receptor by clopidogrel makes it a potent inhibitor of platelet activation and aggregation. In patients with acute coronary syndromes or undergoing percutaneous interventions, combining clopidogrel with aspirin is a crucial approach to antiplatelet therapy. The aim of this review article is to investigate the factors that contribute to clopidogrel resistance, mechanisms involved in clopidogrel resistance, evaluate it through laboratory methods and clinical implications of clopidogrel resistance. Additionally, the article explores the clinical importance of Clopidogrel Resistance and its correlation with harmful cardiovascular events. The paper concludes by proposing potential solutions to this resistance and suggesting the usage of alternative antiplatelet from the new generation.

Keywords

Clopidogrel Resistance; Platelet Aggregation; P2Y12 Receptor; Ticagrelor; “Gold Standard” Method

Download Article PDF

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-1408.pdf

Preview Article PDF

How to cite this article

B. V. Raghavendra, J. Naga Lakshmi, K. Naga Anusha, U. Hari tarun and T. Vijay Kumar. Understanding clopidogrel resistance: Mechanisms, detections, implications and surmount the clopidogrel resistant in order to potential solutions. World Journal of Advanced Research and Reviews, 2023, 19(2), 907-921. Article DOI: https://doi.org/10.30574/wjarr.2023.19.2.1408

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

Developed & Designed by VS Infosolution

Understanding clopidogrel resistance: Mechanisms, detections, implications and surmount the clopidogrel resistant in order to potential solutions

B. V. Raghavendra, J. Naga Lakshmi, K. Naga Anusha, U. Hari tarun and T. Vijay Kumar

Preview Article PDF

Get Certificates

Issue details