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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Therapeutic potential of hedgehog signaling pathway agonist

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  • Therapeutic potential of hedgehog signaling pathway agonist

Kumari Poonam, Sharma Ankita, Singla Shivali * and Goyal Sachin

Himalayan Institute of Pharmacy, Kala-Amb, Sirmour (H.P.), India.
* Corresponding author
 
Review Article
World Journal of Advanced Research and Reviews, 2019, 02(02), 010-016.
Article DOI: 10.30574/wjarr.2019.2.2.0014
DOI url: https://doi.org/10.30574/wjarr.2019.2.2.0014
 
Received on 23 January 2019; revised on 10 June 2019; accepted on 14 June 2019
 
The Hedgehog (Hh) signaling pathway plays an important role in the growth, development, and homeostasis of many tissues in vertebrates and invertebrates in embryonic stage. However, Hh signaling is also involved in postnatal processes such as tissue repair and adult immune responses. To some extent, Hh signaling has also been shown to be a target for some pathogens like HIV, EVB and influenza that presumably utilize the pathway to control the local infected environment. In present review, we discuss the detailed mechanism of the Hedgehog (Hh) signaling pathway involved in various disease being a target. We also give a range of agonist and on the possibility of using small molecule modulators of Hh signaling as effective therapies for a wider range of human diseases.
Hedgehog (Hh); Smoothened (Smo); Agonist; Cancer; Autism
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2019-0014.pdf

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Kumari Poonam, Sharma Ankita, Singla Shivali and Goyal Sachin. Therapeutic potential of hedgehog signaling pathway agonist. World Journal of Advanced Research and Reviews, 2019, 2(2), 0-0. Article DOI: https://doi.org/10.30574/wjarr.2019.2.2.0014

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