1 Departmen of Medical, Bachelor Program of Medical, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Indonesia.
2 Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Indonesia.
3 Department of Biomedic, Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Indonesia.
4 Department of Physiology, Faculty of Medicine, Universitas Brawijaya, Indonesia.
5 Department of Pathology Anatomy, Faculty of Medicine, Universitas Brawijaya, Indonesia.
6 Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Indonesia.
Review Article
World Journal of Advanced Research and Reviews, 2023, 17(01), 934-947
Received on 12 December 2022; revised on 20 January 2023; accepted on 23 January 2023
Until now, the modality of choice for patients with acute myeloid leukemia (AML) is chemotherapy. However, chemotherapy has resulted in severe side effects, especially for AML patients aged over 60 years. In addition, cases of multidrug resistance (MDR) have been reported. Pleurotus ostreatus or oyster mushroom has been widely known to possess anticancer effects. The effect might be elicited by its active ingredients. On the other hand, miRNA as a therapeutic target is thought to interact with the active compounds of Pleurotus ostreatus, thus making it a potential complementary treatment for AML. This review was conducted to determine the effect of the active ingredients in Pleurotus ostreatus through their mechanism of action on certain miRNAs. The review was conducted using 49 literatures that have passed the quality assessment using the CRAAP criteria and the JBI checklist. The literature search was carried out using 4 databases, including PubMed, Research Gate, ProQuest, and Science Direct. The systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The results of the systematic review were synthesized in a narrative review without using statistical tests. In summary, at the molecular level, the active compounds in Pleurotus ostreatus can regulate several miRNAs that affect the proliferation and apoptosis of leukemia cells. In the future, it is necessary to carry out molecular and clinical analysis regarding the relationship between the active compounds of Pleurotus ostreatus and the expression of AML-related miRNAs.
Pleurotus ostreatus; MiRNA; Acute Myeloid Leukemia; PRISMA
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Bernaditha Michelle Lesmana, Aulia Rahmi Pawestri, Michelle Anisa Ujianto, Khonsaa Aadilah, Zahrah Firdaus, Felita Galih Perwita Sari, Edwin Widodo, Eviana Norahmawati, Sofy Permana and Agustina Tri Endharti. Therapeutic implication of Pleurotus ostreatus on microRNAs expression in acute myeloid leukemia: A systematic review. World Journal of Advanced Research and Reviews, 2023, 17(1), 934-947. Article DOI: https://doi.org/10.30574/wjarr.2023.17.1.0123