Tamoxifen resistance mechanisms in breast cancer treatment
School of Biological Sciences, University of the Punjab, Lahore 54500, Pakistan.
Review Article
World Journal of Advanced Research and Reviews, 2020, 08(02), 224-232
Article DOI: 10.30574/wjarr.2020.8.2.0429
Publication history:
Received on 15 October 2020; revised on 24 November 2020; accepted on 25 November 2020
Abstract:
Therapies targeting estrogen receptor (ER) are being widely used to treat ER+ breast cancer patients. Despite early detection and improved survival outcomes, tamoxifen resistance, either intrinsic or acquired- is a major obstacle in effective disease management. Current review will summarize different molecular mechanisms of tamoxifen resistance both intrinsic and acquired in breast cancer treatment. This review not only provides basis to understand the nature of tamoxifen drug resistance but also suggests the mechanisms for its control leading to improved therapeutic interventions.
Keywords:
Breast cancer; drug resistance; chemotherapy; tamoxifen
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0