Systemic iron overload: Review of pathophysiology and clinical-radiological diagnostic approach
1 Department of Medicine and Health Sciences, Universidad del Norte, Barranquilla, Colombia.
2 Department of Internal Medicine, Faculty of Health Sciences, Universidad Libre, Barranquilla, Colombia.
3 Department of Radiology, Grupo CT Scanner, Instituto Nacional de Cardiología, Ciudad de México, México.
Review Article
World Journal of Advanced Research and Reviews, 2024, 22(02), 345–353
Article DOI: 10.30574/wjarr.2024.22.2.1383
Publication history:
Received on 27 March 2024; revised on 04 May 2024; accepted on 06 May 2024
Abstract:
Systemic iron overload is a condition that carries significant implications for health, making it crucial to understand its pathophysiology and the precise clinical and radiological diagnostic methods. This article comprehensively reviews the pathophysiology of iron metabolism, highlighting its crucial role in multiple cellular processes and the regulatory mechanisms that maintain its balance in the body. Furthermore, the diagnostic approach to iron overload is analyzed in detail, reviewing the role of various imaging techniques; highlighting magnetic resonance imaging as a method to develop an accurate and non-invasive assessment of iron load in various tissues.
Keywords:
Systemic iron overload; Iron pathophysiology; Magnetic resonance imaging; Iron deposition patterns; Hemochromatosis; Complications of iron overload; Radiological diagnosis.
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0