1 Department of Pharmaceutical sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
2 Department of Pharmaceutical sciences, Siddhartha Group of institutions, Dehradun, Uttarakhand, India.
3 Department of Pharmaceutical sciences, Om Bio Sciences & Pharma college, Roorkee, Uttarakhand, India.
4 Department of Pharmaceutical sciences, IIMT University, Meerut, Uttar Pradesh, India.
5 Department of Pharmaceutical sciences, Gahlot institute of Pharmacy, Koparkhairne, Navi Mumbai, India.
6 Department of Pharmaceutical sciences, Dayanand College of Pharmacy, Barshi Road, Latur, Maharashtra, India.
Research Article
World Journal of Advanced Research and Reviews, 2023, 18(02), 1280-1293
Article DOI: 10.30574/wjarr.2023.18.2.0968
Received on 18 April 2023; revised on 26 May 2023; accepted on 28 May 2023
Cannabis sativa L. is a significant herbaceous species native to Central Asia that has been utilised for folk medicine and other industrial applications. It is a rich source of cellulosic and woody fibres as well as a treasure trove of phytochemicals. The pharmaceutical and construction industries are both very interested in this plant since its metabolites have powerful bioactivities on humans. Cannabinoids are the most researched class of chemicals, primarily because of the vast range of pharmacological effects they have on humans, including psychoactive effects. The phytoconstituents Apigenin and Alpha-bisabolol were synthesised in the current study, and Cannabis sativa L. phytoconstituent was further studied through in silico screening utilising (PDB ID: 6FYZ) along with spectral characterization NMR (1H and 13C) to confirm the presence of saturated and unsaturated moiety in Cannabis sativa L. phytoconstituents. Apigenin and Alpha-bisabolol, two phytoconstituents found in leaves and flower of Cannabis sativa L., were found to have higher docking scores and glide energies when comapred with the standard drugs like Levetiracetam. Cannabis sativa's phytoconstituent has been shown in in-silico studies to have high anti-epileptic potency, making it a crucial source for novel anti-epileptic/anti-convulsant/anti-seizure medications that in the future will focus on a variety of neurological diseaeses and disorders.
Levetiracetam; Spectral characterization; Epilepsy; Phytoconstitutents; In-silico design; Cannabis sativa L.; Apigenin; Alpha-bisabolol
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Sudhanshu Kumar Jha, Chandan Kumar, Soumya Bharadwaj, Kalpana, Vishakha, Prince Chauhan, Rinkal Doshi and Gopal Lohiya. Synthesis, in-silico design and spectral characterization, elucidation of Cannabis sativa L. cannabaceae containing phytoconstitutents demonstrating novel therapeutic efficacy against epilepsy. World Journal of Advanced Research and Reviews, 2023, 18(2), 1280-1293. Article DOI: https://doi.org/10.30574/wjarr.2023.18.2.0968