Spermatogenic and antiradical activities of the hydro-ethanolic extract of Strychnos camptoneura (longaniaceae) trunk barks in Wistar rats
1 Laboratory of Pharmacology and Biochemistry, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Congo.
2 Laboratory of Animal Physiology, Faculty of Sciences and Technology, Marien Ngouabi University, P.O. Box 69, Brazzaville, Congo.
Research Article
World Journal of Advanced Research and Reviews, 2023, 17(01), 386-394
Article DOI: 10.30574/wjarr.2023.17.1.1287
Publication history:
Received on 24 November 2022; revised on 07 January 2023; accepted on 10 January 2023
Abstract:
The objective of the present study were to evaluate the spermatogenic and antiradical potentialities of the hydro-ethanolic extract of Strychnos camptoneura trunk bark in male wistar rats. For this purpose, 20 rats were divided into 4 lots of 5 animals and received respectively for lots 1 and 2 distilled water and testosterone enanthate. Lots 3 and 4 were treated with the hydro-ethanolic extract of Strychnos camptoneura (100 and 250 mg/kg). The results obtained show that, the administration of hydro-ethanolic extract of Strychnos camptoneura (100 and 250 mg /kg/po) orally in rats caused significant dose-dependent increases (p < 0.05; p < 0.01 and p < 0 .001) in sperm concentration and motility rates compared to rats of the control group treated with distilled water. On the other hand, the vitality rates of sperm and normal sperm were only significant (p < 0.01) at the respective doses of 100 and 250 mg /kg of Strychnos camptoneura compared to the negative controls. In addition, there was no variation in sperm pH (p ˃ 0.05) at any dose level. Chemical analysis of the hydro-ethanol extract of Strychnos camptoneura revealed the existence of phenolic compounds especially polyphenols and total flavonoids endowed with antiradical and antioxidant properties. The improvement of the characteristics of the semen and the reduction of the DPPH radical observed in the present work, justify its biological potentialities and its use in traditional medicine in the treatment of male infertility.
Keywords:
Strychnos camptoneura; Spermatogenic; Antiradical; Male infertility
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