1 Department of Biomedical Sciences, Faculty of Medicine, University of Lubumbashi, DR Congo.
2 Department of Pediatrics, Faculty of Medicine, University of Lubumbashi, DR Congo.
3 Department of Biochemistry, Faculty of Veterinary Medicine, University of Lubumbashi, RD Congo.
Research Article
World Journal of Advanced Research and Reviews, 2024, 23(01), 001-006
Article DOI: 10.30574/wjarr.2024.23.1.1964
Received on 22 May 2024; revised on 01 July 2024; accepted on 03 July 2024
Introduction: Sickle cell disease is an inherited red blood cell disorder that leads to oxidative stress with the consequence of damage to certain organs, including the thyroid.
Objective: To evaluate changes in serum concentrations of triiodothyronine (T3), tetra-iodothyronine (T4) and thyroid-stimulating hormone (TSH) in subjects with sickle cell disease in the city of Lubumbashi.
Methods: This study examined indicators of energy metabolism and a marker of oxidative stress in sickle cell anemia children attending ″The Sickle Cell Care Center (C-fare) ″. (n=64) and healthy control group (n = 64). The serum obtained after centrifugation of venous blood sample, was used for evaluate T3, T4 and TSH concentration. Mean values obtained from patients and the control group were statistically compared using the Student's t test.
Results: Mean values of T3, T4 and TSH in sickle cell anemia children were respectively 1.91 ± 0.60 ng/L; 119.73 ± 25.32 nmol/L and 2.99 ± 1.48 mIU/L. In control group, these values were 2.71 ± 1.22 ng/L; 130.96 ± 28.42 nmol/L and 2.18 ± 5.05 mIU/L respectively. The mean values of T3 and T4 were significantly lower (p < 0.0001) while the mean value of TSH was significantly higher (p < 0.01) in patients compared to the control group.
Conclusion: This study demonstrates that sickle cell disease shows greater incidence of hypothyroidism characterized by a significant decrease in T3 and T 4 with a significant increase in TSH.
SS Anemia; Hemolysis; Oxidative stress; Thyroid Function; Lubumbashi
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Tshibumbu Kabeya Edouard, Kasamba Ilunga Eric, Lungu Anzwal Philomene, Balaka Ekwalanga Michel, Shongo Ya Pongombo Mick, Kazadi Lubobo Claude and Ndibualonji Badibanga Victor. Sickle cell disease and biological assessment of the thyroid gland in Lubumbashi. World Journal of Advanced Research and Reviews, 2024, 23(1), 001-006. Article DOI: https://doi.org/10.30574/wjarr.2024.23.1.1964