Second-degree Heart Block in a Patient on Zanubrutinib

Omar Abbasi; Milliejoan Mongalo; Kush Kapadia; Cristian Valdez; Tony Alarcon; Xenia Schneider

doi:10.30574/wjarr.2024.22.2.1536

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 || CrossRef DOI

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Second-degree Heart Block in a Patient on Zanubrutinib

Omar Abbasi ^{1, *}, Milliejoan Mongalo ¹, Kush Kapadia¹, Cristian Valdez ¹, Tony Alarcon ¹ and Xenia Schneider ²

¹ Department of Internal Medicine, HCA Healthcare; MountainView Hospital, Las Vegas, NV, USA.

² Department of Critical Care, HCA Healthcare; Southern Hills Hospital, Las Vegas, NV, USA.

Case Study

World Journal of Advanced Research and Reviews, 2024, 22(02), 1371-1373

Article DOI: 10.30574/wjarr.2024.22.2.1536

DOI url: https://doi.org/10.30574/wjarr.2024.22.2.1536

Publication history

Received on 08 April 2024; revised on 16 May 2024; accepted on 18 May 2024

Abstract

Zanubrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor recently approved by the Food and Drug Administration for treatment of chronic lymphocytic leukemia (CLL) in January 2023. As a second generation BTK inhibitor, zanubrutinib is more selective for “on-target” BTK and have less cardiac side effects. Although atrial flutter and atrial fibrillation were noted side effects during clinical trials, heart block is not a known side effect. Here we present a case of a patient with CLL on zanubrutinib who presented with a second-degree heart block.

Keywords

CLL; Zanubrutinib; Heart block; Second-degree heart block; BTK inhibitor

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Omar Abbasi, Milliejoan Mongalo, Kush Kapadia, Cristian Valdez, Tony Alarcon and Xenia Schneider. Second-degree Heart Block in a Patient on Zanubrutinib. World Journal of Advanced Research and Reviews, 2024, 22(2), 1371-1373. Article DOI: https://doi.org/10.30574/wjarr.2024.22.2.1536

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Second-degree Heart Block in a Patient on Zanubrutinib

Omar Abbasi ^{1, *}, Milliejoan Mongalo ¹, Kush Kapadia¹, Cristian Valdez ¹, Tony Alarcon ¹ and Xenia Schneider ²

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Second-degree Heart Block in a Patient on Zanubrutinib

Omar Abbasi 1, *, Milliejoan Mongalo 1, Kush Kapadia 1, Cristian Valdez 1, Tony Alarcon 1 and Xenia Schneider 2

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Omar Abbasi ^{1, *}, Milliejoan Mongalo ¹, Kush Kapadia¹, Cristian Valdez ¹, Tony Alarcon ¹ and Xenia Schneider ²