Safety and effectiveness of α-adrenergic blockers for pediatric urolithiasis in the distal Ureter: A systematic review

Medical expulsive therapy is now widely accepted by parents, and pediatric urolithiasis is a common condition. We searched PubMed, Embase, and the Cochrane Library databases for pertinent publications. We considered all published randomized controlled trials (RCTs) on the treatment of pediatric distal urolithiasis with α-adrenergic blockers or placebo. The results included information on stone ejection rate, stone expulsion time, pain episodes, analgesic use, adverse events, and related subgroup analyses. Our findings suggest that well-tolerated α-adrenergic blockers can successfully cure juvenile distal urolithiasis. We also discovered that silodosin is the most effective pharmaceutical approach, with a greater percentage of ejection.