Role of peptidomimetics for new drug discovery
Department of Pharmacognosy and Phytochemistry, Joginpally B R Pharmacy College, Yenkapally, Moinabad, Hyderabad-500075, Telangana, India.
Review Article
World Journal of Advanced Research and Reviews, 2022, 16(02), 271–291
Article DOI: 10.30574/wjarr.2022.16.2.1150
Publication history:
Received on 01 October 2022; revised on 02 November 2022; accepted on 05 November 2022
Abstract:
The art of transforming peptides into drug leads is still a powerful and fertile field in medicinal chemistry and drug discovery. Peptidomimetics can respond to peptide limitations by displaying higher metabolic stability, good bioavailability and increasing receptor affinity and selectivity. Various synthetic approaches and strategies have been developed over the years in order to modulate the conformational flexibility and the peptide nature of peptide mimetic compounds. This review aims to outline useful tools towards peptide mimetic design, spanning from local modifications, global restrictions and the use of secondary structure mimetics. Key learning points: Advantages of peptidomimetics over peptides, definition and classification of peptide mimetics, synthetic strategies and molecules for local modifications, secondary structure mimetics, global restrictions and Applications of peptide mimetics in drug discovery. Selected best examples of each approach are presented to document the relevance of peptidomimetics in new drug discovery.
Keywords:
Peptidomimetics; Drug discovery; Synthetic strategies; Global restrictions; Applications
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0