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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

The role of intralesional immunotherapy in Condyloma Acuminata

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  • The role of intralesional immunotherapy in Condyloma Acuminata

Lita Setyowatie * and Putri Mulia Bela Grania Hasibuan

Department of Dermatology and Venereology, Dr. Saiful Anwar Hospital, Malang City, East Java, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2023, 20(03), 1245-1262
Article DOI: 10.30574/wjarr.2023.20.3.2557
DOI url: https://doi.org/10.30574/wjarr.2023.20.3.2557
 
Received on 05 November 2023; revised on 16 December 2023; accepted on 18 December 2023
 
Intralesional immunotherapy is one of the immunotherapy modalities that can be given to patients with condyloma acuminata (CA) with a high success rate both in inhibiting progression and preventing recurrence of genital warts. Intralesional immunotherapy regimens that are currently being studied are the use of vaccines and cytokines. Some of the antigens studied for use as therapy in genital warts include Candida albicans, measles, mumps and rubella (MMR), and Tuberculin/Purified Protein Derivate (PPD), Mycobacterium w, and Bacille Calmette-Guerin (BCG). Vaccines and cytokines work by inducing a delayed-type hypersensitivity response to warts tissue, both through cellular and humoral immune responses, mediated by CD8+ T lymphocytes, CD4+ T lymphocytes, B lymphocytes and regulatory T cells so that this can eliminate HPV virus infection in CA. This literature review aims to provide an understanding of the use of intralesional immunotherapy as an effective alternative therapy in CA.
 
Intralesional immunotherapy; Condyloma acuminata; Genital warts; Vaccines; Cytokines
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-2557.pdf

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Lita Setyowatie and Putri Mulia Bela Grania Hasibuan. The role of intralesional immunotherapy in Condyloma Acuminata. World Journal of Advanced Research and Reviews, 2023, 20(3), 1245-1262. Article DOI: https://doi.org/10.30574/wjarr.2023.20.3.2557

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