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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

The role of folic acid supplementation on lowering homocysteine level in chronic kidney disease

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  • The role of folic acid supplementation on lowering homocysteine level in chronic kidney disease

Christina Permata Shalim 1, * and Giovanni Reynaldo 2

1 Siloam Hospitals Kebon Jeruk, Jakarta, Indonesia.
2 St. Carolus Hospital, Jakarta, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2023, 17(02), 464-470
Article DOI: 10.30574/wjarr.2023.17.2.0245
DOI url: https://doi.org/10.30574/wjarr.2023.17.2.0245
 
Received on 29 December 2022; revised on 06 February 2023; accepted on 09 February 2023
 
Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients. Elevated homocysteine levels in CKD patients were thought to be one of the causes. Folic acid supplementation, which was known to improve anemia in CKD patients, can also reduce homocysteine levels, which would reduce cardiovascular events. In this review we will discuss the pathophysiology of hyperhomocysteinemia in CKD patients and studies that explain the role of folic acid to lower homocysteine levels that can also lower the risk of CVD in CKD patients. There are some conflicting results among available studies, but folic acid still seems reasonable to be considered as a suitable supplementary therapy in individuals with CKD after a thorough evaluation of the patient's folate status.
 
Cardiovascular disease; Chronic kidney disease; Folate; Folic acid; Homocysteine
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-0245.pdf

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Christina Permata Shalim and Giovanni Reynaldo. The role of folic acid supplementation on lowering homocysteine level in chronic kidney disease. World Journal of Advanced Research and Reviews, 2023, 17(2), 464-470. Article DOI: https://doi.org/10.30574/wjarr.2023.17.2.0245

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