Review of the local tissue reaction to metallic spinal implant debris: Ions and nanoparticles

Magdalena Richter; Henryk Matusiewicz

doi:10.30574/wjarr.2021.9.3.0085

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Review of the local tissue reaction to metallic spinal implant debris: Ions and nanoparticles

Magdalena Richter ¹ and Henryk Matusiewicz ^{2, *}

¹ Department of Orthopedics and Traumatology, Poznan University of Medical Sciences, Poznań, Poland.

² Faculty of Chemical Technology, Poznan University of Technology, Poznań, Poland.

Review Article

World Journal of Advanced Research and Reviews, 2021, 09(03), 167-187

Article DOI: 10.30574/wjarr.2021.9.3.0085

DOI url: https://doi.org/10.30574/wjarr.2021.9.3.0085

Publication history

Received on 02 February 2021; revised on 04 March 2021; accepted on 06 March 2021

Abstract

Biologic reactivity to implant debris is the primary determinant of long-term clinical performance. The metallic implants placed in human bodies can exhibit electrochemical or mechanical corrosion that yields in the liberation of metallic products. Such implants-derived metal wear products can be present in the form of metal ions and particulate metal debris with still unknown effects on human health. In situ generation of metallic wear particles, corrosion products and in vivo trace metal ions release from metal and metallic alloys implanted into the body in spine surgery is becoming a major cause for concern regarding the health and safety of patients. In vivo clinical studies addressing the adverse local tissue reaction effects of metallic wear products on surrounding soft tissues and bodily fluids are less numerous. Although numerous studies have focused on the clinical significance of corrosion and wear of hip and knee replacements, research involving spine instrumentation is not well documented. This review explores how migration of metallic wear nanoparticles and trace metal ions in the area of metallic spinal implants influences the surrounding tissues and bodily fluids, and what the clinical consequences of this process may be.

Keywords

Spine arthroplasty implants; Adverse local tissue reactions; Metallic particles; In vivo metal ion release; Biological fluids and tissues; Analytical methodology

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How to cite this article

Magdalena Richter and Henryk Matusiewicz. Review of the local tissue reaction to metallic spinal implant debris: Ions and nanoparticles. World Journal of Advanced Research and Reviews, 2021, 9(3), 167-187. Article DOI: https://doi.org/10.30574/wjarr.2021.9.3.0085

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Review of the local tissue reaction to metallic spinal implant debris: Ions and nanoparticles

Magdalena Richter ¹ and Henryk Matusiewicz ^{2, *}

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Review of the local tissue reaction to metallic spinal implant debris: Ions and nanoparticles

Magdalena Richter 1 and Henryk Matusiewicz 2, *

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Magdalena Richter ¹ and Henryk Matusiewicz ^{2, *}