Review of drug indications for proton pump inhibitors among hospitalized patients in King Fahd Hospital, Alkobar, Saudi Arabia
1 College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Saudi Arabia.
2 Department of Pharmacy, King Fahd University Hospital, Al Khobar, Saudi Arabia.
Research Article
World Journal of Advanced Research and Reviews, 2020, 06(03), 237-244
Article DOI: 10.30574/wjarr.2020.6.3.0193
Publication history:
Received on 07 June 2020; revised on 19 June 2020; accepted on 22 June 2020
Abstract:
Proton pump inhibitors (PPIs) are among the most commonly prescribed medications worldwide. Irrational use of PPIs is a common practice among hospitalized patients. The major objective of this study was to determine the appropriateness of indications of PPIs among hospitalized patients in King Fahd Hospital, Al Khobar, Saudi Arabia. A cross-sectional study was conducted at King Fahd Hospital, during December 2018 to March 2019. All adult patients admitted to the Medical and Surgical Departments were eligible. Data was collected from each patient’s medical record using a structured - data collection form. Assessment of the appropriateness of PPIs indications was performed based on standardized criteria. Descriptive statistics were used to describe all variables. Regression models were performed to identify the determinants of inappropriateness of PPIs indication. A p-value less than 0.05 was considered as statistically significant. Overall, a total of 181 patients was included, of them 96 (53%) were males. Patients aged > 65 years were 47 (26%). Out of all patients PPIs was prescribed as prophylactic therapy for 163 (90.1%) and for 18 (9.9%) as treatment. For 128 (70.7%) patients PPIs was inappropriately indicated. Multiple logistic regression analysis showed that, age more than 65 years [AOR 8.36 (3.82 - 18.3), (P <0.001)] was significantly associated with appropriate indication of PPIs. PPIs indications was irrational as it was inappropriately prescribed for a considerable number of patients. Urgent interventions are needed to improve the quality of prescribing of this important class of drugs.
Keywords:
Drug; Indications; Proton pump inhibitors
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