Retrospective analysis of early growth patterns in children diagnosed growth hormone deficient during childhood.

Ashraf Soliman 1, *, Fawzia Alyafei 1, Nada Alaaraj 1, Noor Hamed 1, Shayma Ahmed 1 and Nada Soliman 2

1 Department of Pediatrics, Hamad General Hospital, Doha, Qatar.
2 Department of Public health, North Dakota State University, ND, USA.
Research Article
World Journal of Advanced Research and Reviews, 2024, 22(03), 1242–1251
Article DOI: 10.30574/wjarr.2024.22.3.1785
Publication history: 
Received on 04 May 2024; revised on 11 June 2024; accepted on 13 June 2024
This retrospective study examines early growth patterns in children diagnosed with Growth Hormone Deficiency (GHD) during childhood. It highlights the significance of early detection and intervention in managing GHD.
Introduction: Growth Hormone Deficiency (GHD) in early childhood significantly impacts physical development. However, the early growth patterns associated with GHD are not well understood. This retrospective study evaluates the growth trajectories of children diagnosed with GHD, underscoring the critical need for early detection and intervention.
Objectives: The study aims to:
  • Characterize the early growth patterns (Length and Weight Standard Deviation Scores, LTSDS and WTSDS) of children diagnosed with GHD.
  • Evaluate the impact of parental heights on these growth outcomes.
  • Synthesize existing research on GHD growth trajectories.
  • Examine the benefits of early diagnosis.
  • Advocate for enhanced screening and monitoring protocols.
Methods: This retrospective analysis involved reviewing medical records from a regional pediatric endocrinology clinic, focusing on children diagnosed with GHD between 2010 and 2020. The study cohort comprised children who were diagnosed at an average age of 5.2 years (SD = ±1.1 years).
Results: Data from 25 children diagnosed with GHD revealed a consistent negative trend in both LTSDS and WTSDS from birth to 48 months. When compared to WHO growth standards, these children showed a persistent lag in growth, with the most significant deviations occurring between birth and 24 months.
Discussion: The findings highlight the variability in early growth patterns among children with GHD and the potential risks of misdiagnosis or delayed diagnosis due to subtle early symptoms. Prompt diagnosis followed by early intervention is crucial for improving long-term growth and developmental outcomes.
Conclusion: This retrospective analysis confirms that early growth faltering in children with GHD is profound, underscoring the need for early and proactive monitoring. The study advocates for standardized growth tracking protocols, enhanced awareness programs, and expedited referrals for endocrinological assessments to optimize treatment outcomes.
Early infantile detection; Growth Hormone Deficiency (GHD); Growth patterns; Intervention
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