Radiotherapy in advanced recurrent juvenile nasopharyngeal angiofibroma: A case report

Juvenile nasopharyngeal angiofibroma (JNA) is a rare, highly vascular benign tumor characterized by locally aggressive behavior. While surgery remains the standard treatment, management of recurrent or advanced disease with skull base extension remains challenging.

We report the case of a 15-year-old male presenting with recurrent JNA initially treated surgically. The patient subsequently developed recurrence managed with embolization followed by incomplete resection. Further imaging demonstrated locoregional progression with skull base and intracranial extension. Given the extent of disease and limited surgical options, definitive radiotherapy was delivered to a total dose of 50 Gy. Treatment was well tolerated, with no significant acute or late toxicity. At follow-up, the patient showed complete clinical response and progressive radiological regression with no evidence of disease progression.

Radiotherapy represents an effective and well-tolerated treatment option for recurrent or unresectable JNA, particularly in advanced stages when surgical management is not feasible.