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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Quorum Quenching Potential of Autoinducer Ssp(A4K-A11K) in Inhibiting Streptococcus mutans Biofilm Formation

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  • Quorum Quenching Potential of Autoinducer Ssp(A4K-A11K) in Inhibiting Streptococcus mutans Biofilm Formation

Devy Ratriana Amiati *, Nur Dianawati, Ernita Sari, Endah Kusumastuti and Sawitri Dwi Indah Pertami

Department of Oral Biology, Faculty of Dental Medicine, Bhakti Wiyata Institute of Health Sciences, Kediri, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(01), 2606-2610
Article DOI: 10.30574/wjarr.2024.24.1.3255
DOI url: https://doi.org/10.30574/wjarr.2024.24.1.3255
 
Received on 17 September 2024; revised on 24 October 2024; accepted on 26 October 2024.
 
Background: Streptococcus mutans (S. mutans) is a normal flora of the human oral cavity that develops and forms biofilms. S. mutans biofilm can be a problem in the oral cavity and can be a serious problem in systemic health. Autoinducer Ssp(A4K-A11K) is an autoinducer synthesized by the quorum sensing system of Streptococcus gordonii (S. gordonii) which has the ability to inhibit the formation of S. mutans biofilm. This inhibition mechanism is known as quorum quenching.
Objective: To determine the quorum quenching mechanism of autoinducer Ssp(A4K-A11K) in inhibiting S. mutans biofilm formation.
Methods: Article searches using 3 databases namely Pubmed, Science direct, and ProQuest were screened according to inclusion and exclusion criteria.
Results: Autoinducer Ssp(A4K-A11K) is an amino acid with positively charged residues on the α-helix that can inhibit the attachment of S. mutans to the tooth surface and inhibit the formation of the S. mutans Biofilm eDNA structure. In addition, autoinducer Ssp(A4K-A11K) is able to suppress the adhesion of S. mutans by inhibiting the interaction between AgI/II (from S. mutans bacteria) with glycoprotein-340 and hydroxyapatite in the teeth.
Conclusion: Autoinducer Ssp(A4K-A11K) is able to inhibit S. mutans biofilm formation and could be one of the future antibiofilm and anti-caries therapies.
 
Quorum quenching; Ssp(A4K-A11K); Biofilm; Steptococcus mutans
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-3255.pdf

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Devy Ratriana Amiati, Nur Dianawati, Ernita Sari, Endah Kusumastuti and Sawitri Dwi Indah Pertami. Quorum Quenching Potential of Autoinducer Ssp(A4K-A11K) in Inhibiting Streptococcus mutans Biofilm Formation. World Journal of Advanced Research and Reviews, 2024, 24(1), 2606-2610. Article DOI: https://doi.org/10.30574/wjarr.2024.24.1.3255

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