1 Department of Physiology, Veterinary Faculty, Kafkas University, Kars, Turkey.
2 Department of Physiology, Veterinary Faculty, Ataturk University, Erzurum, Turkey.
Research Article
World Journal of Advanced Research and Reviews, 2021, 10(01), 156–161
Article DOI: 10.30574/wjarr.2021.10.1.0155
Received on 10 March 2021; revised on 13 April 2021; accepted on 15 April 2021
In this study, it was aimed to investigate the protective effect of Resveratrol, which has a strong antioxidant effect on kidney tissues of rats experimentally induced with carbon tetrachloride with nephrotoxicity, by kidney function tests and histopathology. For this purpose, 32 male Wistar Albino rats were used. The subjects were randomly selected, 1st group control, 2nd group CCl4, 3rd group Resveratrol. The 4th group was divided into 4 groups as CCl4 + Resveratrol. At the end of the experiment, animals were sacrificed under anesthesia and kidney samples were taken in 10% formalin solution for histopathological analysis. In the histopathological examination, it was found that the rats in the control and Resveratrol groups had normal kidney histological structure. In CCI4 group, severe hydropic degeneration in tubules epithelium, mild coagulation necrosis in tubules epithelium and severe hyperemia in the vessels were observed. When kidney tissues of rats were examined in CCI4 + Resveratrol group, mild hydropic degeneration in tubules epithelium and mild hyperemia in vessels were observed. When the kidney tissues of the rats in the Resveratrol group were examined, it was observed that they had a normal histological appearance. As a result, it was determined that Resveratrol has a protective effect on kidney damage caused by CCI4.
Kidney; CCI4; Rat; Resveratrol; Urea
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Volkan Gelen and Emin Şengül. Protective effects of resveratrol on kidney function tests and renal histopathology in carbon tetrachloride-induced renal toxicity in rats. World Journal of Advanced Research and Reviews, 2021, 10(1), 156-161. Article DOI: https://doi.org/10.30574/wjarr.2021.10.1.0155