Prevention of doxorubicin-induced haematotoxicity by turmeric in Wistar rats
1Department of Biomedical Technology, School of Science Laboratory Technology, University of Port Harcourt, Choba-Port Harcourt, 500272, Rivers State, Nigeria.
2Department of Biomedical Technology, School of Science Laboratory Technology, University of Port Harcourt, Choba-Port Harcourt, 500272, Rivers State, Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2021, 09(03), 096-108
Article DOI: 10.30574/wjarr.2021.9.3.0084
Publication history:
Received on 02 February 2021; revised on 05 March 2021; accepted on 07 March 2021
Abstract:
Doxorubicin is a known anticancer drug used in treatment of various cancers including leukemias, lymphomas, soft-tissue sarcomas and solid tumors. Doxorubicin exerts its toxicity on the blood by causing bone marrow suppression, myelosuppression, pronounced marrow depression and bone marrow depletion, and hypoplasia This study investigated the effect of turmeric on the haematological parameters in doxorubicin-induced oxidative stress in Wistar rats. 54 adult Wistar rats were divided into 9 groups of six animals each. Group 1 animals served as control (normal saline), group 2 animals served as negative control, and received doxorubicin, group 3 animals were given doxorubicin and turmeric, group 4 animals received doxorubicin and vitamin C, group 5 animals received doxorubicin and vitamin E, group 6 animals received doxorubicin, vitamins C and turmeric, group 7 animals received doxorubicin, vitamin E and turmeric, while group 8 animals received doxorubicin, vitamin C and vitamin E and finally, group 9 animals receive doxorubicin, vitamin C, vitamin E and turmeric. The experiment lasted for 28 days and blood samples were collected from each animal from the various groups for haematological assay. Doxorubicin caused a significant decrease in the serum levels of white blood cell count, neutrophil count, lymphocyte count, monocyte count, platelet count, red blood cell count, hemoglobin concentration, hematocrit and mean corpuscular volume. These changes were prevented by turmeric alone or in combined concomitant administration with vitamins C and or E and doxorubicin
Keywords:
Haematotoxicity; Doxorubicin; Turmeric; Wistar rats
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