The practical approach of Immuno histochemical markers in Solitary Fibrous Tumour (SFT)

Renuka Bangalore Nagaraj 1, Anil Kumar Moodalbeedu Rajegowda 2, Murali Paramanandhan 3, Shivanna 2 and Basavarajaiah Doddagangavadi Mariyappa 4, *

1 Department of Pathology, National Institute of Unani Medicine, Bangalore, Karnataka, India.
2 Oncoville Cancer Hospital and Research Centre, Nagarbhavi, Bengaluru, India.
3 Department of Pediatrics, Bowring and Lady Curzon Hospital, Bengaluru, India.
4 Department of Statistics, Computer Science, KVAFSU (B), Hebbal, Bengaluru, India.
 
Research Article
World Journal of Advanced Research and Reviews, 2022, 13(02), 325–330
Article DOI: 10.30574/wjarr.2022.13.2.0095
 
Publication history: 
Received on 23 December 2021; revised on 31 January 2022; accepted on 02 February 2022
 
Abstract: 
A solitary fibrous tumour is an unknown neoplasm that is fibroblastic in nature. It causes diagnostic difficulty due to its unexpected Immunophenotypic appearance as well as wide histologic appearance, but most of the time it is accurately diagnosed due to its histological characteristics and strong positivity to CD34 expression.SFT is known to occur in almost all parts of the body including meninges and skin. This is a slow-growing neoplasm that can be successfully treated by complete excision; the malignant counterpart of SFT is rare. The most important and reliable positive markers in SFT are CD34, CD99, BCL2. There are consistently negative markers in this tumor as well, used according to the tumor location, such as EMA&S100.Although the majority of SFT can be accurately diagnosed due to histological characteristics and frequent CD34 expression, a wide histologic spectrum and the occurrence of an unexpected immunophenotype might offer diagnostic difficulties. Research findings shows that, the meninges, orbit, upper respiratory tract, salivary glands, thyroid, peritoneum, liver, retroperitoneum, pelvis, adrenal gland, kidney, urinary bladder, vagina, spinal cord, skin, periosteum, and soft tissues have all been known to have this form of neoplasm.
 
Keywords: 
Solitary fibrous tumour; IHC; Mesenchymal
 
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Copyright information: 
Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0

 

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