Potential use of bovine amniotic membrane in periodontal tissue engineering: A literature review

Neira Najatus Sakinah 1, *, Melok Aris Wahyukundari 1, Desi Sandra Sari 1, Peni Pujiastuti 1, Depi Praharani 1, Yuliana Mahdiyah Da’at Arina 1 and Ernie Maduratna 2

1 Department of Periodontology, Faculty of Dentistry, Universitas Jember, Jember, Indonesia.
2 Department of Periodontology, Faculty of Dentistry, Universitas Airlangga, Surabaya, Indonesia.
Review Article
World Journal of Advanced Research and Reviews, 2024, 22(03), 081–089
Article DOI: 10.30574/wjarr.2024.22.3.1646
Publication history: 
Received on 20 April 2024 revised on 28 May 2024; accepted on 30 May 2024
The goal of periodontal treatment is to reduce inflammation and regenerate the defects. As the structure of periodontium is composed of four types of different tissue (cementum, alveolar bone periodontal ligament, and gingiva), the regeneration should allow different cell proliferation in the separated spaces. However, it was difficult to achieve. Need a barrier membrane for epithelial exclusion to promote the healing of periodontal tissues in such a way that the original structure and function are preserved instead of repairing with junctional epithelium. During the occlusive period, the cells including cementoblast, osteoblast, osteoclast, and mesenchymal cells from PDL are activated to rebuild their missing tissues. The human amniotic membrane (HAM) has been used as a barrier membrane in furcation defects, intrabony defects, and gingival recession coverage. The HAM is associated with several problems, such as difficulty in finding donors, so that insufficient to provide mass production for this material. The use of HAM has also led to legal and religious concerns because they must be extracted from the human body. Therefore, the use of Bovine Amniotic Membrane (BAM) as an alternative might address the above limitations, making mass production possible without the ethical concerns of using human material.
Bovine Amniotic Membrane; Stem cell; Tissue engineering; Periodontal regeneration
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