1 Faculty of Dental Medicine, Universitas Airlangga, Jalan Prof Dr Moestopo No 47 Surabaya 60132 Indonesia.
2 Department of Oral Biology, Faculty of Dental Medicine, Universitas Airlangga, Jalan Prof Dr Moestopo No 47 Surabaya 60132 Indonesia.
3 Department of Maxillofacial Anatomy and Neuroscience, Graduate School of Biomedical and Health Science, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8553 Japan.
Research Article
World Journal of Advanced Research and Reviews, 2023, 20(02), 587-592
Article DOI: 10.30574/wjarr.2023.20.2.2299
Received on 01 October 2023; revised on 08 November 2023; accepted on 10 November 2023
Background: Bone homeostasis is maintained by a balance between bone formation by osteoblasts and bone resorption by osteoclasts. As a therapeutic agent for osteoporosis, a strategy of suppressing bone resorption by inhibiting the function of osteoclasts is used; however, long-term use causes problems, such as decreased formation of osteoblasts and osteonecrosis of the jaw. Therefore, various growth factors and hormones have been used to promote the proliferation of osteoblasts, but the current situation is that long-term use cannot be applied owing to issues such as carcinogenic risk. To establish an appropriate osteogenesis-promoting strategy, it is essential to ensure the fate of progenitor cells in the mature osteoblasts.
Purpose: To investigate potential osteogenic regulators based on published single-cell transcriptome data as an alternative approach to bone diseases treatment.
Methods: a systematic review using articles through several databases with descriptions related to various genes were identified based on single-cell transcriptome data as candidates for osteogenic regulators.
Results: 20 unexplored genes were identified based on single-cell transcriptome data as candidates for osteogenic regulators.
Conclusions: Increasing osteoblast activity through the promotion of osteoblast differentiation shows promise as a novel approach for treating bone-formation-related diseases.
Bone Homeostasis; Osteoblast; Bone Diseases; Gene Expression.
Preview Article PDF
Akromuna Ishmah, Aqsa Sjuhada Oki and Shohei Kohno. Potential of 20 unexplored genes to be candidates for osteogenic regulators as novel therapeutic strategies in bone diseases. World Journal of Advanced Research and Reviews, 2023, 20(2), 587-592. Article DOI: https://doi.org/10.30574/wjarr.2023.20.2.2299