1 Department of pharmaceutical chemistry, Lahore Pharmacy College, Lahore, Pakistan.
2 Department of pharmacology, Lahore Pharmacy College, Tulspura, Lahore, Pakistan.
3 Faculty of pharmacy, B.Z.U. Multan, Pakistan.
Research Article
World Journal of Advanced Research and Reviews, 2021, 11(01), 215–220
Article DOI: 10.30574/wjarr.2021.11.1.0335
Received on 17 June 2021; revised on 26 July 2021; accepted on 28 July 2021
The present study evaluates the phytochemical screening, analgesic and anti-inflammatory properties of aqueous and methanolic extracts from the root of Oligomeris linifolia (OL). Pain responses were studied in mice using acetic acid writhing method and in rats using the hot plate and formalin test. The effect of the extract on edema induced by 1.5% carrageenan was also investigated. The extracts of OL exhibited significant anti-nocicetive properties against acetic acid induced abdominal constrictions in mice. In the rat the extract exhibited significant analgesic activity as evidence by (i) increased escaped latency on hot plate in the extract-treated rats and (ii) reduction in formalin-induced pain. The maximum edema rates attained in the rats pre-treated with 150mg/kg of aqueous and methanol extracts of OL (12.50 ± 2.88%, P<0.005 and 21.63 ± 3.21%, P<0.05 respectively) were significantly lower than the control value (32.62 ± 5.33%). Aspirin (150mg/kg) gave a maximum edema rate of 13.04 ± 1.98% (P<0.005). The results provide preliminary evidence for the anecdotal use of Oligomeris linifolia by traditional medical practitioners in the management of pain and inflammation.
Oligomeris linifolia: Phytochemical; Analgesic; Anti-inflammatory
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Khuram Ashfaq, Muhammad Tariq, M Abuzar Ghaffari and Sajid N Hussain. Phytochemical screening, analgesic and anti-inflammatory activities from root extracts of Oligomeris linifolia. World Journal of Advanced Research and Reviews, 2021, 11(1), 215-220. Article DOI: https://doi.org/10.30574/wjarr.2021.11.1.0335