Pattern of breast cancer presentation in a tertiary hospital in Lagos, Nigeria
Department of Surgery, Federal Medical Centre, Ebute-Metta, Lagos. Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2020, 05(02), 048-059
Article DOI: 10.30574/wjarr.2020.5.2.0014
Publication history:
Received on 19 January 2020; revised on 27 January 2020; accepted on 04 February 2020
Abstract:
Breast cancer is a major public health issue all over the world. While morbidity and mortality are reducing in developed world, they are rather very high in developing countries. This study was designed to determine the pattern of breast cancer in our patients, including the associated risk factors, the commonest molecular types, commonest age and stage of presentation. Consecutive patients diagnosed with Breast Cancer following Tru-cut biopsy, at any stage were recruited. Immunohistochemistry was done using the biopsy specimen. A well-structured questionnaire was prepared and administered after taking oral consent. History was taken and physical examination done. Data was analyzed by IBM SSPS Statistics 24. We had 189 respondents, age range 25-77years, 187 females and 2 males. Commonest presenting complaint was breast lump only (54%), commonest age at presentation was 41-50years (29.6%). Stage at presentation was stage III (48.7%). The predominant histological type is Invasive Ductal Carcinoma (74.3%). standardized (regression) coefficients of history of breast cancer (1.267), presence of other cancers in the family (1.560) and smoking (1.206) suggests that they are associated risk factors for breast cancer. The predominant molecular subtype is Lumina A (29%) and 44.8% were triple negative.
Keywords:
Breast cancer; Triple negative breast cancer (TNBC); Immunohistochemistry (IHC); Invasive Ductal Carcinoma; Estrogen Receptor (ER); Progesterone receptor (PR)
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0