An overview on synthesis and biological activity of pyrimidines
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Helwan, Egypt.
Review Article
World Journal of Advanced Research and Reviews, 2022, 15(01), 272–296
Article DOI: 10.30574/wjarr.2022.15.1.0689
Publication history:
Received on 05 June 2022; revised on 09 July 2022; accepted on 11 July 2022
Abstract:
Pyrimidines represent an important class of heterocycles containing two nitrogen atoms at position 1 and 3 of the six membered ring show wide range of biological activities. Numerous methods for the synthesis of pyrimidine and their diverse reactions offer enormous scope in the field of medicinal chemistry. Pyrimidine possesses wide spectrum of biological activities including antitubercular, antibacterial, antifungal, antiviral, anti-inflammatory, antimalarial, anticancer, and anti-HIV activity. The present review attempts to give brief information about the synthesis and various biological activities of pyrimidines and their derivatives.
Keywords:
Pyrimidine; pyrimidine derivatives; Synthesis; Biological activities
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