1 Weihai Qiaotou Hospital, Weihai, Shandong, China.
2 Weihai Municipal Hospital, Weihai, Shandong, China.
3 Weihaiwei People's Hospital, Weihai, Shandong, China.
Research Article
World Journal of Advanced Research and Reviews, 2019, 04(02), 307-312
Article DOI: 10.30574/wjarr.2019.4.2.0156
Received on 09 December 2019; revised on 23 December 2019; accepted on 29 December 2019
Inflammatory infiltrates in the pelvic region represent a common complication after surgical interventions on pelvic organs, often leading to prolonged hospitalization, increased pain, and potential long-term sequelae such as adhesions. This original prospective study, conducted from June 2017 to June 2019, aimed to evaluate the efficacy of adjunctive rectal suppositories containing streptokinase (15,000 IU) and streptodornase (1,250 IU) in addition to standard treatment guidelines for managing these complications. A total of 110 patients were divided into two groups: Group 1 (n=55) received standard anti-inflammatory and antibiotic therapy, while Group 2 (n=55) received the same plus the suppositories. The suppository regimen varied by disease severity: for severe cases, one suppository three times daily for three days, then twice daily for three days, and once daily for three days; for moderate to mild cases, twice daily for three days followed by once daily for four days or twice daily for two days. Results demonstrated superior outcomes in Group 2, including faster reduction in infiltrate volume (p<0.05 at multiple time points), reduced hospital stay (mean 12.4 vs. 18.2 days, p<0.01), fewer severe cases (10.9% vs. 25.5%, p<0.05), lower complication rates (14.5% vs. 30.9%, p<0.05), diminished pain scores (p<0.05), and reduced post-recovery adhesions (20.0% vs. 41.8%, p<0.05). These findings suggest that enzymatic suppositories enhance resolution of pelvic inflammatory infiltrates, potentially improving patient outcomes.
Pelvic Surgery Complications; Inflammatory Infiltrates; Streptokinase; Streptodornase; Rectal Suppositories; Non-Surgical Treatment
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Yanting LOU, Guangcan Chen LI, Qi Hao HOU, Denis Mak CHI, Lo YAU and Marek Y. NITSETSKYI. Non-surgical treatment of inflammatory complications following pelvic organ surgeries. World Journal of Advanced Research and Reviews, 2019, 4(2), 307-312. Article DOI: https://doi.org/10.30574/wjarr.2019.4.2.0156