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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Non-aspirin NSAIDs use is associated with lowering of liver fibrosis scores in patients with fatty liver disease

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  • Non-aspirin NSAIDs use is associated with lowering of liver fibrosis scores in patients with fatty liver disease

Ikechukwu Ronald Ogbu 1, Hossein Akhondi asl 2, Napatkamon Ayutyanont 3, Andre Manov 4 and Vignan Manne 5, *

1 Internal Medicine Department, Mountain View Hospital Sunrise Health Consortium, Las Vegas, NV.
2 Associate Program Director, Mountain View Hospital Associate Professor of Medicine, University of Nevada.
3 Division Director of Research HCA Far West Division, Las Vegas, NV.
4 Associate Program Director, Mountain View Hospital   Professor of Medicine, TCU and UNTHSC School of Medicine, Fort Worth, TX.
5 Gastroenterology Fellowship Department, Southern Hills Hospital and Medical Center, Las Vegas, NV.
 
Research Article
World Journal of Advanced Research and Reviews, 2021, 10(01), 230-236
Article DOI: 10.30574/wjarr.2021.10.1.0165
DOI url: https://doi.org/10.30574/wjarr.2021.10.1.0165
 
Received on 14 March 2021; revised on 19 April 2021; accepted on 21 April 2021
 
Only a few studies are available with appropriate data on the effects of non-aspirin, non-steroidal anti-inflammatory drugs (NSAIDs) use in patients with fatty liver disease. We performed a retrospective study of 1347 patients with imaging studies that showed fatty liver disease from 2016 through 2019. We then determined the change in validated indices using Fibrosis-4 (FIB4) and NAFLD fibrosis score (NFS). Patient clinical information, including NSAIDs use, was collected at baseline and then yearly. Using generalized linear models, we estimated the association between non-aspirin NSAIDs use and change in baseline indices. Non-aspirin NSAIDs use was found to be associated with significant lowering of FIB-4 score (0.596 units lower, p-value <0.0001) and NFS (0.431 units lower, p-value 0.0027) every year.
In this retrospective study of patients with fatty liver disease found on imaging, non-aspirin NSAID use was associated with lowering of fibrosis scores, suggesting that NSAID use might be associated with a lower risk for advanced fibrosis in fatty liver disease.
 
Fatty liver disease; NSAIDs; Aspirin; Ibuprofen; liver fibrosis; Advance liver disease, Cirrhosis, liver fibrosis indices, NAFLD score, Fibrosis-4 score
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2021-0165.pdf

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Ikechukwu Ronald Ogbu, Hossein Akhondi asl, Napatkamon Ayutyanont, Andre Manov and Vignan Manne. Non-aspirin NSAIDs use is associated with lowering of liver fibrosis scores in patients with fatty liver disease. World Journal of Advanced Research and Reviews, 2021, 10(1), 230-236. Article DOI: https://doi.org/10.30574/wjarr.2021.10.1.0165

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