1 Department of Biochemistry, Era’s Lucknow Medical College and Hospital, ERA University, Lucknow Uttar Pradesh India.
2 Department of Pathology, Era’s Lucknow Medical College and Hospital, ERA University, Lucknow Uttar Pradesh India.
Review Article
World Journal of Advanced Research and Reviews, 2024, 23(02), 1610-1614
Received on 07 July 2024; revised on 16 August 2024; accepted on 19 August 2024
A wide spectrum of progressive neurological disorders with a multifactorial etiology that contributes to the pathophysiology of the disease are collectively referred to as nervous system disorders (NSDs). A number of molecular and cellular processes, including oxidative stress, mitochondrial malfunction, protein misfolding, excitotoxicity, and inflammation, are involved in this intricate process. One current method of studying the degenerative process of the disease is to investigate the role of genes, as genetic forms of degenerative diseases are rather uncommon. Thus, it has been hypothesized that close interactions between genetic and environmental factors are responsible for idiopathic forms of the diseases; the genetic component may favor or even protect against the disease process. Owing to their wide range of biological and pharmacological activities, natural compounds may be suitable options for the treatment of these complex morbidities. Nevertheless, their low bioavailability and consequently inadequate brain delivery have limited their therapeutic potential against neurodegenerative diseases. An overview of the molecular mechanisms underlying the neuroprotective effects of natural compounds is given in this article.
ROS; NSDs; CNS; Alzheimer’s; Parkinson’s
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Pushpendra D. Pratap and Sharique Ahmad. A neuroprotective approach towards nature’s goods for nervous system disorders: Current update. World Journal of Advanced Research and Reviews, 2024, 23(2), 1610-1614. Article DOI: https://doi.org/10.30574/wjarr.2024.23.2.2501