Neuropathology of major psychiatric disorders: A systematic review
Department of Psychiatry & Behavioral Neurosciences, Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians, Suite E-132.
Review Article
World Journal of Advanced Research and Reviews, 2022, 15(02), 381–392
Article DOI: 10.30574/wjarr.2022.15.2.0761
Publication history:
Received on 21 June 2022; revised on 25 July 2022; accepted on 27 July 2022
Abstract:
Objective: The purpose of this paper is to review literature on the neuropathology of major psychiatric disorders.
Methods: Systematic reviews of neuropathology of psychiatric disorders were identified from 1972 to 2022 through the use of the PubMed database, using the keywords: ‘neuropathology’ AND ‘schizophrenia’ OR ‘bipolar’ OR ‘major depression’. The search was then narrowed to systematic reviews.
Results: Ten systematic reviews were selected in this review. The neuropathological findings were identified and detailed for schizophrenia, bipolar disorder, and major depression, at the macroscopic and microscopic levels.
Conclusion: Most of the Psychiatric disorders showed cortical damage in certain areas of the brain especially the cingulate cortex, temporal lobe, and the amygdala. The main limitation of interpreting neuropathological findings in major psychiatric disorders is simply identifying and analyzing brain samples of sufficient quantity and quality for research.
Keywords:
Neuropathology; Schizophrenia; Bipolar; Depression; Pathology
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