Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia
1 Department of Pediatrics, Mohammed Al Mousawi Hospital, Thi-qar.
2 Department of Pediatrics, Basrah Medical College, University of Basrah.
3 Department of Pediatrics, Alzahraa Medical College, University of Basrah.
Research Article
World Journal of Advanced Research and Reviews, 2021, 12(03), 264–270
Article DOI: 10.30574/wjarr.2021.12.3.0696
Publication history:
Received on 10 November 2021; revised on 13 December 2021; accepted on 15 December 2021
Abstract:
Background: Liver cell injury commonly occurs after perinatal asphyxia. This study aimed to identify the neonatal and maternal factors related to hepatic dysfunction associated with birth asphyxia.
Methods: A case control study was carried out in Basra comprising 43 asphyxiated newborns, and 57 healthy full terms enrolled as control. Serum levels of liver enzymes [alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP)] were measured and compared between the study and control groups. Levels beyond +2SD above the mean of control considered high. Statistical analysis was done using SPSS program version 20. Chi-Square test and ANOVA were used where appropriate, P-value <0.05 was considered as significant. Elevated levels of enzymes were studied in relation to selected neonatal and maternal variables.
Results: Higher levels of liver enzymes were found related to gestational age > 40 weeks, newborn’s body weight > 4 Kg, mother’s age>35 years, parity > 4 children and maternal medical disease. The results were statistically significant (P<0.05). However, no statistical differences were detected regarding newborn’s gender and growth status, maternal education and mode of delivery.
Conclusion: The study highlights the relationship between maternal and neonatal risk factors and perinatal asphyxia associated with hepatic dysfunction.
Keywords:
Aspartate; Control; Gender; Parity
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Copyright © 2021 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0