Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia

Asmaa M Lafta; Aida A Manther; Miami K Yousif

doi:10.30574/wjarr.2021.12.3.0696

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 || CrossRef DOI

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Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia

Asmaa M Lafta ¹, Aida A Manther ² and Miami K Yousif ^{3, *}

¹ Department of Pediatrics, Mohammed Al Mousawi Hospital, Thi-qar.

² Department of Pediatrics, Basrah Medical College, University of Basrah.

³ Department of Pediatrics, Alzahraa Medical College, University of Basrah.

Research Article

World Journal of Advanced Research and Reviews, 2021, 12(03), 264-270

Article DOI: 10.30574/wjarr.2021.12.3.0696

DOI url: https://doi.org/10.30574/wjarr.2021.12.3.0696

Publication history

Received on 10 November 2021; revised on 13 December 2021; accepted on 15 December 2021

Abstract

Background: Liver cell injury commonly occurs after perinatal asphyxia. This study aimed to identify the neonatal and maternal factors related to hepatic dysfunction associated with birth asphyxia.

Methods: A case control study was carried out in Basra comprising 43 asphyxiated newborns, and 57 healthy full terms enrolled as control. Serum levels of liver enzymes [alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP)] were measured and compared between the study and control groups. Levels beyond +2SD above the mean of control considered high. Statistical analysis was done using SPSS program version 20. Chi-Square test and ANOVA were used where appropriate, P-value <0.05 was considered as significant. Elevated levels of enzymes were studied in relation to selected neonatal and maternal variables.

Results: Higher levels of liver enzymes were found related to gestational age > 40 weeks, newborn’s body weight > 4 Kg, mother’s age>35 years, parity > 4 children and maternal medical disease. The results were statistically significant (P<0.05). However, no statistical differences were detected regarding newborn’s gender and growth status, maternal education and mode of delivery.

Conclusion: The study highlights the relationship between maternal and neonatal risk factors and perinatal asphyxia associated with hepatic dysfunction.

Keywords

Aspartate; Control; Gender; Parity

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Asmaa M Lafta, Aida A Manther and Miami K Yousif. Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia. World Journal of Advanced Research and Reviews, 2021, 12(3), 264-270. Article DOI: https://doi.org/10.30574/wjarr.2021.12.3.0696

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Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia

Asmaa M Lafta ¹, Aida A Manther ² and Miami K Yousif ^{3, *}

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Neonatal and maternal factors associated with hepatic dysfunction after birth asphyxia

Asmaa M Lafta 1, Aida A Manther 2 and Miami K Yousif 3, *

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Issue details

Asmaa M Lafta ¹, Aida A Manther ² and Miami K Yousif ^{3, *}