Morphine at inflammatory experimental pain: A review

Hugo F. Miranda; Viviana Noriega; Francisca Moreno; Fernando Sierralta; Ramón Sotomayor-Zárate; Juan Carlos Prieto

doi:10.30574/wjarr.2022.15.1.0675

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 || CrossRef DOI

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Morphine at inflammatory experimental pain: A review

Hugo F. Miranda ^1,^*, Viviana Noriega ^{2, 3}, Francisca Moreno ⁴, Fernando Sierralta ⁵, Ramón Sotomayor-Zárate ⁶and Juan Carlos Prieto ^{3, 5}

¹ Neuroscience Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

² Faculty of Medicine, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile.

³ Cardiovascular Department, Clinical Hospital, Universidad de Chile, Santiago, Chile.

⁴ Faculty of Medicine, Diego Portales University, Santiago, Chile.

⁵ Pharmacology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

⁶ Centro de Neurobiology Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Review Article

World Journal of Advanced Research and Reviews, 2022, 15(01), 116-121

Article DOI: 10.30574/wjarr.2022.15.1.0675

DOI url: https://doi.org/10.30574/wjarr.2022.15.1.0675

Publication history

Received on 01 June 2022; revised on 03 July 2022; accepted on 05 July 2022

Abstract

Pain is a complex entity that can be described in several dimensions, such as, acute pain and chronic pain, characterized by its duration. After the tissue injury, the activation of the sensory nervous tissue occurs from where the different pro-inflammatory mediators are released with the consequent nociceptive transmission that characterizes the genesis of inflammatory pain. The main objective of this study was to review the role of the opioid system, using morphine and MOR opioid receptors as paradigm, in the antinociceptive modulation of inflammatory pain, by means of the formalin test as a model. Various pieces of evidence are compiled that establish the fundamental role of morphine in the inflammatory pain. Morphine has noticeable antinociceptive efficacy in to decrease the inflammatory pain. This review demonstrates the fundamental role that morphine plays in inflammatory pain states and that it could serve as the basis for a new pharmacotherapy of inflammatory pain.

Keywords

Morphine; Formalin assay; Inflammatory pain; Glia

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Hugo F. Miranda, Viviana Noriega, Francisca Moreno, Fernando Sierralta, Ramón Sotomayor-Zárate and Juan Carlos Prieto. Morphine at inflammatory experimental pain: A review. World Journal of Advanced Research and Reviews, 2022, 15(1), 116-121. Article DOI: https://doi.org/10.30574/wjarr.2022.15.1.0675

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Morphine at inflammatory experimental pain: A review

Hugo F. Miranda ^1,^*, Viviana Noriega ^{2, 3}, Francisca Moreno ⁴, Fernando Sierralta ⁵, Ramón Sotomayor-Zárate ⁶and Juan Carlos Prieto ^{3, 5}

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Morphine at inflammatory experimental pain: A review

Hugo F. Miranda 1, *, Viviana Noriega 2, 3, Francisca Moreno 4, Fernando Sierralta 5, Ramón Sotomayor-Zárate 6 and Juan Carlos Prieto 3, 5

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Hugo F. Miranda ^1,^*, Viviana Noriega ^{2, 3}, Francisca Moreno ⁴, Fernando Sierralta ⁵, Ramón Sotomayor-Zárate ⁶and Juan Carlos Prieto ^{3, 5}