Modulation of apoptotic pathways by Trypanosoma cruzi and its relationship with the progression of heart disease in the host
Departamento de Biociências, Universidade Federal de São Paulo, Campus Baixada Santista, Brasil.
Review Article
World Journal of Advanced Research and Reviews, 2020, 07(02), 146-154
Article DOI: 10.30574/wjarr.2020.7.2.0292
Publication history:
Received on 06 August 2020; revised on 11 August 2020; accepted on 18 August 2020
Abstract:
Chagas disease, a parasitic infection caused by the intracellular protozoan Trypanosoma cruzi, affects millions of people worldwide, and South American countries are among the most affected. This disease has a clinical course that varies from the acute asymptomatic phase to the chronic phase with the presence of important alterations that compromise the cardiac and digestive systems. Studies have shown that the life cycle of the parasite impacts on the modulation of apoptosis, revealing a complex pathogen-host interaction that can substantially influence the development of cardiac alterations. This intriguing strategy used by Trypanosoma cruzi has been increasingly explored and thus it is expected to be able to better clarify the events that precede the development of chagasic cardiomyopathy.
Keywords:
Chagas' disease; Myocarditis; Cardiomyopathy; Apoptosis, T. cruzi
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0