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eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

Mixed corticotropic and somatotropic pituitary adenoma: A case report

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  • Mixed corticotropic and somatotropic pituitary adenoma: A case report

CAMARA M’BALLOU *, RAFI SANA, El MGHARI GHIZLANE and El ANSARI NAWAL

Department Endocrinology, Diabetology and Metabolic Diseases, PCIM Laboratory, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech, Morocco.
 
Case Study
World Journal of Advanced Research and Reviews, 2023, 17(02), 735-738
Article DOI: 10.30574/wjarr.2023.17.2.0298
DOI url: https://doi.org/10.30574/wjarr.2023.17.2.0298
 
Received on 08 January 2023; revised on 20 February 2023; accepted on 23 February 2023
 
Multi-secreting pituitary adenomas are relatively rare. The mixed somatotropic and corticotropic pituitary adenoma is very rare. The most widely described association is that coupling hypersecretion of GH and prolactin. We report the case of a patient with a pituitary adenoma bi-secreting GH and ACTH.
He was a 28-year-old patient admitted for pituitary tumor syndrome, cushing syndrome. The hormonal assessment found a dependent ACTH cushing syndrome. The other hypothalamohypophysial axes were without abnormality. The hypothesis of a pituitary adenoma was raised. The brain scan confirmed the diagnosis by showing a macroadenoma with supra-sellar development with infiltration of the cavernous sinus. After trans-sphenoidal surgery, there was a complete regression ofcushing syndrome. The pathology examination showed a pituitary adenoma; at immunohistochemistry cells expressing anti-ACTH and anti - GH antibodies with KI 67 at 1%.
 
Pituitary Adenoma; Plurihormonal adenoma; Cushing; Somatotropic
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2023-0298.pdf

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CAMARA M’BALLOU, RAFI SANA, El MGHARI GHIZLANE and El ANSARI NAWAL. Mixed corticotropic and somatotropic pituitary adenoma: A case report. World Journal of Advanced Research and Reviews, 2023, 17(2), 735-738. Article DOI: https://doi.org/10.30574/wjarr.2023.17.2.0298

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