Microsponge: An adaptable topical drug delivery system
Department of pharmaceutics, East Point College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bidarahalli, Bengaluru-49, Karnataka, India.
Review Article
World Journal of Advanced Research and Reviews, 2022, 15(01), 396–411
Article DOI: 10.30574/wjarr.2022.15.1.0694
Publication history:
Received on 06 June 2022; revised on 15 June 2022; accepted on 17 June 2022
Abstract:
Microsponge a drug delivery system, possesses the versatility to load a wide range of active ingredients due large surface area. it facilitates controlled release of active ingredients and reduces systemic exposure and adverse effect. microsponges are polymeric sponges that consist of interconnecting voids with a flexible structure with a porous surface. Microsponge delivery techniques provides extended product stability, enhanced safety, enhanced formulation flexibility, product efficacy and aesthetic appeal with reduced adverse effects. It is regarded as safe, due to less bacterial contamination as it doesn’t require preservatives in the formulation. Therefore it is used in various sterile formulations like ophthalmic, parenteral etc. This review provides an overview of microsponge technology with its methodology, mechanism, programmable release, characterization and recent data on marketed formulations, their applications, and the list of patents, evaluation and application of microsponges in various aspects. Microsponge are frequently used for topical application but recently used for oral also.
Keywords:
Microsponge; Sustain release; Stability; Drug delivery; Preservative; Anti-fungal
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Copyright © 2022 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0