Department of Microbiology, Immunology and Parasitology, Experimental Oncology Unit, Federal University of São Paulo, São Paulo, SP, Brazil.
Review Article
World Journal of Advanced Research and Reviews, 2022, 15(02), 393-404
Article DOI: 10.30574/wjarr.2022.15.2.0844
Received on 12 July 2022; revised on 13 August 2022; accepted 15 August 2022
The different types of tissues of the human body age in different ways; Cells that undergo many divisions such epithelial and connective tissues if compared to neurons and muscle have different aging mechanisms. Thus, we propose a thesis that, cell nucleus is composed of a macrostructural machinery, whit mechanisms of control the number of mitotic divisions and chronological markers of cell age. So, the macro molecular proteins structures in telomeres called shelterin and proteins known as lamins that are core integrity conformational proteins of the nucleus would perform functions of cellular age as structural timers. Finally, in certain tissues an accumulation of a truncated lamin known as progerin and the shortening of telomeres in shelterin complex has a mechanical function in molecular machinery of the nucleus where they work a compression in the transcriptionally structure of active euchromatin, with advancing of age this compression would decrease the rate of transcription of many genes, and causing the aging of organism.
Core molecular biology; Theories of aging; Mutations; Study models of aging
Preview Article PDF
Eric Almeida Xavier. The macromolecular machinery of the nucleus in the senescence process. World Journal of Advanced Research and Reviews, 2022, 15(2), 393-404. Article DOI: https://doi.org/10.30574/wjarr.2022.15.2.0844