Insomnia in patients with heart disease: A systematic review

Waguih William IsHak 1, 2, *, Mohadese Golsorkhi 1, Ariella Maghen 1, Laurel Tay 1, Salma Abdelmoteleb 1, Salma Ramadan 1, Samuel Korouri 1, Michele Hamilton 3 and Itai Danovitch 1

1 Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

2 David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

3 Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

 
Review Article
World Journal of Advanced Research and Reviews, 2023, 20(01), 287–309
Article DOI: 10.30574/wjarr.2023.20.1.2029
 
Publication history: 
Received on 14 August 2023; revised on 02 October 2023; accepted on 04 October 2023
 
Abstract: 
Objective: The purpose of this paper is to review the literature on insomnia in patients with heart disease in order to answer the following questions: (a) What is the impact of insomnia on quality of life, morbidity, and mortality in patients with heart disease? (b) What is the impact of treatment interventions on insomnia in patients with heart disease?
Methods: Following the PRISMA guidelines, studies published from 1973 to 2023 that pertain to insomnia and heart disease were identified through the use of the PubMed and PsycINFO databases, using the keywords: ‘cardiac’ OR ‘cardiovascular’ OR ‘heart’ AND ‘disease’ AND ‘insomnia’. Two authors independently conducted a focused analysis and reached a final consensus on 11 studies that met the specific selection criteria and passed the study quality checks.
Results: Management of insomnia in patients with heart disease involved combining different interventions, such as CBT-I with disease management or self-management programs, which demonstrated sustained improvements in sleep-related metrics in patients with heart disease and insomnia. While non-pharmacological approaches were the primary focus in most studies reviewed, medication-based interventions, such as zolpidem controlled-release, melatonin, and oxazepam, showed promising results.
Conclusion: The findings support the use of CBT-I as an effective non-pharmacological approach for managing insomnia in patients with heart disease. Future research should explore the long-term effects of interventions, optimal dosing and duration, and potential synergistic effects of combining different interventions.
 
Keywords: 
Insomnia; Heart Disease; Treatment; Interventions.
 
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