Inhibition of untranslated region, subgenomic RNA, and TMPRSS2 for SARS cov-2.
Microbiology Department, Faculty of science, Tanta University, Tanta, Egypt.
Review Article
World Journal of Advanced Research and Reviews, 2020, 08(03), 350-355
RETRACTED
Publication history:
Received on 07 November 2020; revised on 12 December 2020; accepted on 14 December 2020
Abstract:
The SARS CoV-2 genome contains untranslated region (UTR) which regulates RNA replication and transcription, and subgenomic RNA (sgRNA) which encodes the 4 structural proteins where the virus cannot proliferate without them. The SARS CoV-2 host cell contains TMPRSS2 protease enzyme which activates the virus to enter the cell. The chemical compounds Peptide Conjugated Phosphorodiamidate morpholino Oligomer (PPMO) and Benzylesulfonyl-d-arginine-proline-4-amidinobenzylamide (BAPA) have prevented the TMPRSS2 expression in influenza host cell. PPMO also has inhibited the UTR of influenza genome and the sgRNA of porcine reproductive and respiratory syndrome virus (PRRSV), so PPMO and BAPA could inhibit the UTR and sgRNA of SARS CoV-2, and prevent the expression of TMPRSS2 in SARS CoV-2 host cell, that prevents virus replication. This may open the way for the development of anti SARS CoV-2 therapy.
RETRACTED
According to the retraction notice:
This article has been retracted at the request of the Editors. The authors acknowledge there are serious errors in the content. Apologies are offered to the readers of the journal that this was not brought to the Editors’ attention during the peer review process.
Keywords:
SARS CoV-2; Influenza virus; porcine reproductive and respiratory syndrome virus; Peptide Conjugated Phosphorodiamidate morpholino Oligomer; Benzylesulfonyl-d-arginine-proline-4-amidinobenzylamide; Drug
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Copyright © 2020 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0