Immunological markers of rheumatoid arthritis in the Moroccan population
1 Department of Immunology and Transfusion, Ibn Sina Hospital Center, Rabat, Morocco.
2 UPR of Immunology, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
3 Department of Rheumatology B, El Ayachi Hospital, Ibn Sina Hospital Center, Faculty of Medicine and Pharmacy,
Mohammed V University, Rabat, Morocco.
4 Day clinic, delegation of the Ministry of Health to the prefecture of Rabat, Regional Hospital Center, Rabat, Morocco.
5 International University of Rabat (UIR), Rabat, Morocco.
Research Article
World Journal of Advanced Research and Reviews, 2024, 23(01), 2044–2053
Publication history:
Received on 09 June 2024; revised on 17 July 2024; accepted on 19 July 2024
Abstract:
Aim: few studies exist on HLA-DRB1 alleles and their association with RA in North Africa. We aimed to provide an evaluation of the distribution of the HLA-DRB1* and -DQB1* genes in Moroccan patients with early RA. Additionally, we sought to analyze the relationship between HLA molecules and the production of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies (anti-CCP) in these patients.
Methods: 65 patients with rheumatoid arthritis benefited from HLA class II typing (DRB1* and DQB1*) and testing for anti-CCP and RF antibodies. The frequency of HLA alleles was compared to that of 180 healthy controls. Logistic regression analysis was used to investigate the association of HLA-DR and -DQ molecules in the different subgroups according to anti-CCP and RF status.
Results: The frequency of HLA-DRB1*04 and *11 alleles is increased in patients compared to controls (OR = 1.9; 95% CI (1.06-3.30), P=0.029; OR=2, 95% CI (1-3.83, P=0.047, respectively). 56 patients (86.1%) were RF positive, and 67.7% were anti-CCP positive. A significant increase in the frequency of DRB1*04 alleles was also noted in seropositive patients.
Conclusion: Our results suggest the predisposition of the HLA-DRB1*04 allele and the seropositive status of patients with RA. This could be useful in predicting the evolution of RA and establishing a diagnosis in some patients at an early stage of disease use.
Keywords:
Rheumatoid Arthritis; Rheumatoid Factor; Anti-Cyclic Citrullinated Peptides; HLA-DRB1; Moroccan Population
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0