HIV-1 and IgA Antibodies: Interactions and implications

Bennani Kenza; Mahmoud Mustapha; Yahyaoui Ghita; Kouara Sara

doi:10.30574/wjarr.2024.23.2.2337

eISSN: 2581-9615 || CODEN: WJARAI || Impact Factor 8.2 || CrossRef DOI

Research and review articles are invited for publication in April 2026 (Volume 30, Issue 1) Submit manuscript

HIV-1 and IgA Antibodies: Interactions and implications

Bennani Kenza ^{1, 2, *}, Mahmoud Mustapha ^{1, 2}, Yahyaoui Ghita ^{1, 2} and Kouara Sara ^{1, 2}

¹ Department of Bacteriology-Virology, Central Laboratory of Medical Analysis, CHU Hassan II, Fez, Morocco.

²Faculty of Medicine, Pharmacy and Dental Medicine of Fes, University of Sidi Mohamed Ben Abdellah, Fez, Morocco.

Review Article

World Journal of Advanced Research and Reviews, 2024, 23(02), 126-133

Article DOI: 10.30574/wjarr.2024.23.2.2337

DOI url: https://doi.org/10.30574/wjarr.2024.23.2.2337

Publication history

Received on 23 June 2024; revised on 31 July 2024; accepted on 02 August 2024

Abstract

Antibodies, particularly Immunoglobulin A (IgA), play a crucial role in mucosal tissues as immune effectors against pathogens and as immunomodulators of the microbiota. During infection with human immunodeficiency virus type 1 (HIV-1), a systemic and mucosal IgA antibody response is triggered. Although naturally produced serum IgA specific to HIV-1 envelope protein are quantitatively and qualitatively lower than their IgG counterparts, they also possess antiviral properties such as neutralization and Fc-dependent effector functions. Neutralizing IgA antibodies can block mucosal transmission of HIV-1 in animal models, suggesting that their induction through vaccination could be pivotal for infection prevention. Recently, broadly neutralizing IgA antibodies have been identified in some individuals living with HIV-1. Given the potential for vaccination to induce these mucosally protective antibodies, research efforts are needed to better understand their development and functions. This review discusses the general roles of IgA antibodies in homeostasis and antimicrobial immunity, and explores their implications in antibody responses during HIV-1 infection.

Keywords

HIV-1; Neutralizing antibodies; IgA; Therapeutic target

Download Article PDF

https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-2337.pdf

Preview Article PDF

How to cite this article

Bennani Kenza, Mahmoud Mustapha, Yahyaoui Ghita and Kouara Sara. HIV-1 and IgA Antibodies: Interactions and implications. World Journal of Advanced Research and Reviews, 2024, 23(2), 126-133. Article DOI: https://doi.org/10.30574/wjarr.2024.23.2.2337

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

Developed & Designed by VS Infosolution

HIV-1 and IgA Antibodies: Interactions and implications

Bennani Kenza ^{1, 2, *}, Mahmoud Mustapha ^{1, 2}, Yahyaoui Ghita ^{1, 2} and Kouara Sara ^{1, 2}

Preview Article PDF

Get Certificates

Issue details

HIV-1 and IgA Antibodies: Interactions and implications

Bennani Kenza 1, 2, *, Mahmoud Mustapha 1, 2, Yahyaoui Ghita 1, 2 and Kouara Sara 1, 2

Preview Article PDF

Get Certificates

Issue details

Bennani Kenza ^{1, 2, *}, Mahmoud Mustapha ^{1, 2}, Yahyaoui Ghita ^{1, 2} and Kouara Sara ^{1, 2}