High temperature manufactured Corbicula japonoca shell powder (Carcite type crystal structure) improved diabetes in mouse
1 Department of Clinical Immunology, Hirosaki University School of Health Sciences, 66-1 Honcho, Hirosaki 036-8565, Japan.
2 Joint Department of Veterinary Clinical Medicine, Faculty of Agriculture, Tottori University. 4-101 Koyama-Minami, Tottori 680-8553, Japan.
3 NEO CIRCLE Co., Ltd, 4-8-6 Akasaka Minatoku, Tokyo 107-0052, Japan.
4 FUJICLEANTECH Co., Ltd. 1-1-40 Aoyagi, Aomori 038-0004, Japan.
Research Article
World Journal of Advanced Research and Reviews, 2022, 15(02), 186–190
Article DOI: 10.30574/wjarr.2022.15.2.0788
Publication history:
Received on 29 June 2022; revised on 06 August 2022; accepted on 08 August 2022
Abstract:
The Carcite type of Corbicula japonica shell powder developed at high temperature 500℃ had improved mal-function of liver in the LEC rat liver disorder model, and restored its function. Additional a new bio-function of the fired shell powder was lately found to lower the blood sugar level in the Type 2 diabetes model mouse (KK/TaJcl). These mice were raised with 2.5% shell powder for a month showed the significant lower level of blood sugar at 81±23mg to that of the control raised without shell powder at 208±86mg (P = .05). Fat globlues deposition and vacuoles formation in the liver were clearly less in the shell powder-fed group compared to those of the control group in histo-pathological inspections. Anti-diabetes efficiency of the Carcite type shell powder prepared at 500℃ 2hrs treatment acquired a blood sugar reduction ability suggesting applicability against the human diabetes patients.
Keywords:
Multi-functional calcium; Corbicula japonica calcite; Diabetes; Blood sugar level improvement; Type 2 diabetes mouse model
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