Department of Science Technology, School of Science and Computer Studies, The Federal Polytechnic, Ado Ekiti, Ekiti State Nigeria.
Research Article
World Journal of Advanced Research and Reviews, 2024, 24(01), 956-963
Received on 02 September 2024; revised on 10 October 2024; accepted on 12 October 2024
Alterations in haematological parameters are frequently observed in individuals with diabetes mellitus (DM). Oxidative stress has been identified as a contributing factor in the pathogenesis of organ damage and haematological dysfunction associated with DM. As a result, the potential positive impact of Moringa oleifera, a medicinal plant known for its antioxidant properties, on haematological parameters and kidney function in diabetic rats was investigated. A total of thirty-five rats were divided into seven groups, each consisting of five rats. Group I was administered only distilled water, while groups II to VII were induced with a single dose of 60mg/kg streptozotocin intraperitoneally. Subsequently, groups II to VI were treated with 150 mg/kg Moringa oleifera leaf methanol extract, 150 mg/kg Moringa oleifera bark methanol extract, 300 mg/kg Moringa oleifera leaf, 300 mg/kg Moringa oleifera bark, and metformin, respectively. The results showed positive modulation to most of the haematology parameters evaluated except neutrophils and lymphocytes by the treatments. The leaf extract showed a more significant modulation of platelets than other treatments. The histology of the kidney showed normal structure for all the treatments. Moringa oleifera especially the leaf extract is promising in the treatment of DM
Moringa oleifera; Haematology; Kidney; Oxidative stress
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Ayonposi Bukola OLAOYE, Waheed Abimbola OYELADE and Kayode Solomon IDOWU. Haematology and histology studies on Moringa oleifera leaves and bark extracts in streptozotocin-induced diabetic albino rats. World Journal of Advanced Research and Reviews, 2024, 24(1), 956-963. Article DOI: https://doi.org/10.30574/wjarr.2024.24.1.3095