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eISSN: 2582-8185 || CODEN: WJARAI || Impact Factor 8.2 ||  CrossRef DOI

Research and review articles are invited for publication in March 2026 (Volume 29, Issue 3) Submit manuscript

Growth factors and puberty in thalassemia adolescents

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  • Growth factors and puberty in thalassemia adolescents

Selia Nirmalantika Marbun 1, Muhammad Faizi 2, *, Merlyna Savitri 3 and Mia Ratwita Andarsini 4

1 Medical Program Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
2 Département of Paediatrics, Faculty of Medicine Airlangga University/RSUD Dr. Soetomo Surabaya, Surabaya, Indonesia.
3 Department of Medical Oncology Haematology, RSUD Dr. Soetomo Surabaya, Surabaya, Indonesia.
4 Département of Paediatrics, Faculty of Medicine Airlangga University/RSUD Dr. Soetomo Surabaya, Surabaya, Indonesia.
 
Review Article
World Journal of Advanced Research and Reviews, 2024, 24(03), 2843-2846
Article DOI: 10.30574/wjarr.2024.24.3.3987
DOI url: https://doi.org/10.30574/wjarr.2024.24.3.3987
 
Received on 16 November 2024; revised on 26 December 2024; accepted on 28 December 2024
 
Thalassemia is a genetic disorder that affects hemoglobin synthesis, causing chronic anemia that contributes to delayed growth and puberty in adolescents. This literature review discusses the factors underlying these delays, such as chronic anemia, iron overload due to repeated blood transfusions, and hormonal dysfunction. Oxygen deficiency due to anemia disrupts metabolic processes and endocrine function, especially in the pituitary axis and gonads, leading to delayed puberty. Effective treatment strategies include routine blood transfusions to maintain hemoglobin levels, iron chelation therapy to prevent endocrine damage, and hormonal interventions to treat growth and puberty disorders. Early detection and regular monitoring are essential to optimize outcomes for adolescent patients with thalassemia.
 
Thalassemia; Growth; Puberty; Adolescents
 
https://wjarr.com/sites/default/files/fulltext_pdf/WJARR-2024-3987.pdf

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Selia Nirmalantika Marbun, Muhammad Faizi, Merlyna Savitri and Mia Ratwita Andarsini. Growth factors and puberty in thalassemia adolescents. World Journal of Advanced Research and Reviews, 2024, 24(3), 2843-2846. Article DOI: https://doi.org/10.30574/wjarr.2024.24.3.3987

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