Green robusta coffee and its hepatoprotective effect on ALT levels of white mice induced with Monosodium Glutamate
Faculty of Medicine, Hang Tuah University, Komplek Barat RSAL Dr. Ramelan, Jl. Gadung, No.1, Jagir, Kec. Wonokromo, Surabaya, Jawa Timur 60244, Indonesia.
Research Article
World Journal of Advanced Research and Reviews, 2024, 21(01), 2671–2674
Article DOI: 10.30574/wjarr.2024.21.1.0328
Publication history:
Received on 14 December 2023; revised on 25 January 2024; accepted on 27 January 2024
Abstract:
Background of the study: Liver injury or damage to liver function, also known as hepatotoxicity, can occur due to various reasons, including chemical substances. Monosodium Glutamate (MSG) is one such chemical that can cause liver damage if consumed in large amounts for a prolonged period. This study aimed to determine the effect of green Robusta Coffee extract on the alanine aminotransferase (ALT) levels of white mice induced with MSG.
Material and methods: This research study used 24 male white mice (Rattus norvegicus) divided into three groups. The negative control group (C-) was given nothing, the positive control group (C+) was given MSG at a dosage of 5 mg/g/day, and the experimental group (E) was given MSG at a dosage of 5 mg/g/day and green Robusta Coffee extract at a dosage of 250 mg/kg/day for 14 days.
Results: On the 15th day, blood was drawn from all three groups to measure ALT levels. The ALT levels were then analyzed using SPSS statistics. The study found a significant increase in ALT levels in the C+ group compared to the C- group (P<0.05). However, there was no significant increase or decrease in ALT levels between the experimental group (E) and the C- and C+ groups (P>0.05).
Conclusion: The study concluded that MSG induction of 5 mg/g/day for 14 days significantly increased the ALT levels of white mice. However, giving green Robusta Coffee (Coffea canephora) extract at a dosage of 250 mg/kg/day did not have a significant effect on the increased ALT enzyme levels of white mice induced with MSG at a dosage of 5 mg/g/day for 14 days.
Keywords:
Hepatotoxicity; Monosodium Glutamate; Green Robusta Coffee; ALT levels
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